SETD1A Human Gene Knockout Kit (CRISPR)
SETD1A - human gene knockout kit via CRISPRchange donor?
HDR-mediated knockout kit validation
KN214996G1, SETD1A gRNA vector 1 in pCas-Guide vector
KN214996G2, SETD1A gRNA vector 2 in pCas-Guide vector
donor DNA containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||NM_014712, XM_005255723, XM_006721106, XM_017023909|
|Synonyms||KMT2F; Set1; Set1A|
|Summary||The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily. [provided by RefSeq, Dec 2016]|
|Gene Expression Resources|