SH3PXD2B Human Gene Knockout Kit (CRISPR)
SH3PXD2B - human gene knockout kit via CRISPRchange donor?
HDR-mediated knockout kit validation
KN214270G1, SH3PXD2B gRNA vector 1 in pCas-Guide vector
KN214270G2, SH3PXD2B gRNA vector 2 in pCas-Guide vector
donor DNA containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||NM_001017995, NM_001308175, XM_017009351|
|Synonyms||FAD49; FTHS; HOFI; KIAA1295; TKS4; TSK4|
|Summary||This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome (FTHS), and also Borrone Dermato-Cardio-Skeletal (BDCS) syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015].|
|Gene Expression Resources|