EPHA8 Human Gene Knockout Kit (CRISPR)
EPHA8 - human gene knockout kit via CRISPRchange donor?
HDR-mediated knockout kit validation
KN213963G1, EPHA8 gRNA vector 1 in pCas-Guide vector
KN213963G2, EPHA8 gRNA vector 2 in pCas-Guide vector
donor DNA containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||BC038796, NM_001006943, NM_020526, XM_011540969, XM_011540970, XM_011540972, XM_011540973, XM_011540975, XR_946576|
|Synonyms||EEK; EK3; HEK3|
|Summary||This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008].|
|Gene Expression Resources|