12 Lipoxygenase (ALOX12) Human Gene Knockout Kit (CRISPR)

CAT#: KN210211RB

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ALOX12 - human gene knockout kit via CRISPR, HDR mediated

HDR-mediated knockout kit validation

  See Other Versions

USD 1,290.00

2 Weeks

    • 1 kit

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Product Data
Format 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control
Symbol 12 Lipoxygenase
Locus ID 239
Kit Components

KN210211G1, 12 Lipoxygenase gRNA vector 1 in pCas-Guide CRISPR vector

KN210211G2, 12 Lipoxygenase gRNA vector 2 in pCas-Guide CRISPR vector

KN210211RB-D, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector

Disclaimer The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000697
Synonyms 12-LOX; 12S-LOX; LOG12
Summary This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]

Other Versions

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Customer Reviews 
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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