TIE1 Human Gene Knockout Kit (CRISPR)

CAT#: KN207771

TIE1 - human gene knockout kit via CRISPR

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USD 1,290


Availability*
4 Weeks

Size
    • 1 kit

Product images

Specifications

Product Data
Symbol TIE1
Locus ID 7075
Kit Components

KN207771G1, TIE1 gRNA vector 1 in pCas-Guide vector,

KN207771G2, TIE1 gRNA vector 2 in pCas-Guide vector,

KN207771-D, donor vector containing Left and right homologous arms and GFP-puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector

Disclaimer The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001253357, NM_005424, XM_005271163, XM_006710869, XM_017002207, XR_946751
Synonyms JTK14; TIE
Summary This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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