RORC Human Gene Knockout Kit (CRISPR)
RORC - human gene knockout kit via CRISPRchange donor?
HDR-mediated knockout kit validation
KN206541G1, RORC gRNA vector 1 in pCas-Guide vector
KN206541G2, RORC gRNA vector 2 in pCas-Guide vector
donor DNA containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||BC031554, NM_001001523, NM_005060, XM_006711484|
|Synonyms||IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR|
|Summary||The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].|
|Gene Expression Resources|