CLPS Human Gene Knockout Kit (CRISPR)
CLPS - human gene knockout kit via CRISPRchange donor?
KN205004G1, CLPS gRNA vector 1 in pCas-Guide vector,
KN205004G2, CLPS gRNA vector 2 in pCas-Guide vector,
donor vector containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||NM_001252597, NM_001252598, NM_001832|
|Summary||The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].|
|Gene Expression Resources|
"CLPS" in other Product Lines
Related Products (2)
Mouse monoclonal anti-GAPDH antibody, clone 2D9, Loading, clone OTI2D9 (formerly 2D9)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control