COQ6 Human Gene Knockout Kit (CRISPR)
COQ6 - human gene knockout kit via CRISPRchange donor?
KN204353G1, COQ6 gRNA vector 1 in pCas-Guide vector,
KN204353G2, COQ6 gRNA vector 2 in pCas-Guide vector,
donor vector containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||NM_015940, NM_182476, NM_182480, XM_006720156, XM_011536807, XM_011536808, XM_011536809, XM_011536810, XM_017021351, XM_017021352, XR_001750342, XR_943465, XR_943466|
|Synonyms||CGI-10; CGI10; COQ10D6|
|Summary||The protein encoded by this gene belongs to the ubiH/COQ6 family. It is an evolutionarily conserved monooxygenase required for the biosynthesis of coenzyme Q10 (or ubiquinone), which is an essential component of the mitochondrial electron transport chain, and one of the most potent lipophilic antioxidants implicated in the protection of cell damage by reactive oxygen species. Knockdown of this gene in mouse and zebrafish results in decreased growth due to increased apoptosis. Mutations in this gene are associated with autosomal recessive coenzyme Q10 deficiency-6 (COQ10D6), which manifests as nephrotic syndrome with sensorineural deafness. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2012].|
|Gene Expression Resources|
"COQ6" in other Product Lines
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