HNRNPDL Human Gene Knockout Kit (CRISPR)
HNRNPDL - human gene knockout kit via CRISPRchange donor?
KN204064G1, HNRNPDL gRNA vector 1 in pCas-Guide vector,
KN204064G2, HNRNPDL gRNA vector 2 in pCas-Guide vector,
donor vector containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||NM_001207000, NM_005463, NM_031372, NR_003249|
|Synonyms||HNRNP, JKTBP, JKTBP2, laAUF1;HNRNP; JKTBP; JKTBP2; laAUF1; A+U-rich element RNA binding factor; heterogeneous nuclear ribonucleoprotein D-like|
|Summary||This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD. [provided by RefSeq, May 2011].|
|Gene Expression Resources|
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