LTA Human Gene Knockout Kit (CRISPR)
LTA - human gene knockout kit via CRISPRchange donor?
HDR-mediated knockout kit validation
KN203741G1, LTA gRNA vector 1 in pCas-Guide vector
KN203741G2, LTA gRNA vector 2 in pCas-Guide vector
donor DNA containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||NM_000595, NM_001159740, XM_011514615, XM_011514616, XM_011514617, XM_011514618|
|Synonyms||LT; TNFB; TNFSF1; TNLG1E|
|Summary||Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. [UniProtKB/Swiss-Prot Function]|
|Gene Expression Resources|