CYP39A1 Human Gene Knockout Kit (CRISPR)
CYP39A1 - human gene knockout kit via CRISPRchange donor?
KN203058G1, CYP39A1 gRNA vector 1 in pCas-Guide vector,
KN203058G2, CYP39A1 gRNA vector 2 in pCas-Guide vector,
donor vector containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||NM_001278738, NM_001278739, NM_016593, XM_005249171, XM_011514658, XM_017010921, XM_017010922, XM_017010923, XM_017010924, XM_017010925|
|Summary||This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].|
|Gene Expression Resources|
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