MATR3 Human Gene Knockout Kit (CRISPR)
MATR3 - human gene knockout kit via CRISPRchange donor?
HDR-mediated knockout kit validation
KN202020G1, MATR3 gRNA vector 1 in pCas-Guide vector
KN202020G2, MATR3 gRNA vector 2 in pCas-Guide vector
donor DNA containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||NM_001194954, NM_001194955, NM_001194956, NM_001282278, NM_018834, NM_199189, NR_036535|
|Synonyms||ALS21; MPD2; VCPDM|
|Summary||This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X. [provided by RefSeq, Aug 2013].|
|Gene Expression Resources|