RFC2 Human Gene Knockout Kit (CRISPR)
RFC2 - human gene knockout kit via CRISPRchange donor?
KN201138G1, RFC2 gRNA vector 1 in pCas-Guide vector,
KN201138G2, RFC2 gRNA vector 2 in pCas-Guide vector,
donor vector containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||NM_001278791, NM_001278792, NM_001278793, NM_002914, NM_181471, XM_006716080, XM_017012492, XM_017012493, XR_927506|
|Summary||This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2. [provided by RefSeq, Jul 2013].|
|Gene Expression Resources|
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