IVD Human Gene Knockout Kit (CRISPR)

CAT#: KN201077

IVD - human gene knockout kit via CRISPR

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 HDR-mediated knockout kit validation

USD 1,290.00


Availability*
4 Weeks

Size
    • 1 kit

Product images

Specifications

Product Data
Symbol IVD
Locus ID 3712
Kit Components

KN201077G1, IVD gRNA vector 1 in pCas-Guide vector

KN201077G2, IVD gRNA vector 2 in pCas-Guide vector

KN201077-D, donor DNA containing Left and right homologous arms and GFP-puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector

Disclaimer The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001159508, NM_001354597, NM_001354598, NM_001354599, NM_001354600, NM_001354601, NM_002225, NR_148923, NR_148924, NR_148925, XM_005254350, XM_006720492, XM_006720495, XM_017022149, XM_017022150, XM_017022151, XM_017022152, XM_017022153, XM_017022154, XM_017022155, XM_017022156, XM_017022157, XM_017022158, XR_001751260, XR_001751262, XR_001751263, XR_001751264, XR_429453
Synonyms ACAD2
Summary Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009].
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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