p53 (TP53) Human Gene Knockout Kit (CRISPR)
CAT#: KN200003RB
TP53 - human gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro Luciferase-Puro mBFP-Neo
HDR-mediated knockout kit validation
USD 1,657.00
2 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
Donor DNA | RFP-BSD |
Symbol | p53 |
Locus ID | 7157 |
Components |
KN200003G1, p53 gRNA vector 1 in pCas-Guide CRISPR vector KN200003G2, p53 gRNA vector 2 in pCas-Guide CRISPR vector KN200003RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_000546, NM_001126112, NM_001126113, NM_001126114, NM_001126115, NM_001126116, NM_001126117, NM_001126118, NM_001276695, NM_001276696, NM_001276697, NM_001276698, NM_001276699, NM_001276760, NM_001276761 |
UniProt ID | P04637 |
Synonyms | BCC7; LFS1; P53; TRP53 |
Summary | This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016] |
Documents
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Other Versions
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KN200003 | TP53 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN200003BN | TP53 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN200003LP | TP53 - human gene knockout kit via CRISPR, HDR mediated |
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KN400003 | TP53 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,657.00 |
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GA104942 | TP53 CRISPRa kit - CRISPR gene activation of human tumor protein p53 |
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