Mouse Shkbp1 activation kit by CRISPRa

CAT#: GA212705

Shkbp1 CRISPRa kit - CRISPR gene activation of mouse Sh3kbp1 binding protein 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Shkbp1
• Locus ID: 192192
• Kit Components:

  GA212705G1, Shkbp1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA212705G2, Shkbp1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA212705G3, Shkbp1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_138676
• UniProt ID: Q6P7W2
• Synonyms: B930062H15Rik; Sb1
• Summary: Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation (PubMed:21830225).[UniProtKB/Swiss-Prot Function]