Mouse Atg7 activation kit by CRISPRa

CAT#: GA209799

Atg7 CRISPRa kit - CRISPR gene activation of mouse autophagy related 7

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Atg7
• Locus ID: 74244
• Kit Components:

  GA209799G1, Atg7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA209799G2, Atg7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA209799G3, Atg7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001253717, NM_001253718, NM_028835
• UniProt ID: Q9D906
• Synonyms: 1810013K23Rik; Agp7; Apg7l; Atg7l; Gm21553
• Summary: This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]