Mouse Ace2 activation kit by CRISPRa

CAT#: GA208393

Ace2 CRISPRa kit - CRISPR gene activation of mouse angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Ace2
• Locus ID: 70008
• Kit Components:

  GA208393G1, Ace2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA208393G2, Ace2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA208393G3, Ace2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001130513, NM_027286
• UniProt ID: Q8R0I0
• Synonyms: 2010305L05Rik
• Summary: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. May have a protective role in acute lung injury. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19, regulating its trafficking on the cell surface and its activity (PubMed:19185582).[UniProtKB/Swiss-Prot Function]