Mouse Orc4 activation kit by CRISPRa

CAT#: GA204970

Orc4 CRISPRa kit - CRISPR gene activation of mouse origin recognition complex, subunit 4

Product images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Orc4
• Locus ID: 26428
• Kit Components:

  GA204970G1, Orc4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA204970G2, Orc4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA204970G3, Orc4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001177313, NM_011958, NR_033442, NR_149355, NR_149356, NM_001355296, NM_011958.4
• Synonyms: mMmORC4; Orc4l; Orc4P
• Summary: Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.[UniProtKB/Swiss-Prot Function]