Mouse Pten activation kit by CRISPRa

CAT#: GA203446

Pten CRISPRa kit - CRISPR gene activation of mouse phosphatase and tensin homolog

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Pten
• Locus ID: 19211
• Kit Components:

  GA203446G1, Pten gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA203446G2, Pten gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA203446G3, Pten gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008960
• UniProt ID: O08586
• Synonyms: 2310035O07Rik; A130070J02Rik; AI463227; B430203M17Rik; MMAC1; TEP1
• Summary: This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains four structural domains, a PIP2-binding domain, a catalytic tensin-type phosphatase domain, a C2 tensin-type domain and a PDZ-binding domain. The protein belongs to the protein tyrosine phosphatase family. Deletion of this gene in mice contribute to tumorigenesis in multiple tissues. [provided by RefSeq, Sep 2015]