Human ATG5 activation kit by CRISPRa

CAT#: GA106330

ATG5 CRISPRa kit - CRISPR gene activation of human autophagy related 5

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: ATG5
• Locus ID: 9474
• Kit Components:

  GA106330G1, ATG5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106330G2, ATG5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106330G3, ATG5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286106, NM_001286107, NM_001286108, NM_001286111, NM_004849, NR_104402, NR_104403
• UniProt ID: Q9H1Y0
• Synonyms: APG5; APG5-LIKE; APG5L; ASP; hAPG5
• Summary: The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]