Human Parkin (PARK2) activation kit by CRISPRa

CAT#: GA103386

PRKN CRISPRa kit - CRISPR gene activation of human parkin RBR E3 ubiquitin protein ligase

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: PRKN
• Locus ID: 5071
• Kit Components:

  GA103386G1, Parkin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103386G2, Parkin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103386G3, Parkin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004562, NM_013987, NM_013988
• UniProt ID: O60260
• Synonyms: AR-JP; LPRS2; PDJ; PRKN
• Summary: The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]