Human Myostatin Propeptide (MSTN) activation kit by CRISPRa

CAT#: GA101775

MSTN CRISPRa kit - CRISPR gene activation of human myostatin

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: MSTN
• Locus ID: 2660
• Kit Components:

  GA101775G1, Myostatin Propeptide gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101775G2, Myostatin Propeptide gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101775G3, Myostatin Propeptide gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005259
• UniProt ID: O14793
• Synonyms: GDF8; MSLHP
• Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016]