Human DVL1 activation kit by CRISPRa

CAT#: GA101303

DVL1 CRISPRa kit - CRISPR gene activation of human dishevelled segment polarity protein 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: DVL1
• Locus ID: 1855
• Kit Components:

  GA101303G1, DVL1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101303G2, DVL1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101303G3, DVL1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004421, NM_181870, NM_182779, NM_001330311
• UniProt ID: O14640
• Synonyms: DRS2; DVL; DVL1L1; DVL1P1
• Summary: DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]