Human NQO1 activation kit by CRISPRa

CAT#: GA101198

NQO1 CRISPRa kit - CRISPR gene activation of human NAD(P)H quinone dehydrogenase 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: NQO1
• Locus ID: 1728
• Kit Components:

  GA101198G1, NQO1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101198G2, NQO1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101198G3, NQO1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000903, NM_001025433, NM_001025434, NM_001286137
• UniProt ID: P15559
• Synonyms: DHQU; DIA4; DTD; NMOR1; NMORI; QR1
• Summary: This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]