Human Adenosine A1 Receptor (ADORA1) activation kit by CRISPRa

SKU GA100093

ADORA1 CRISPRa kit - CRISPR gene activation of human adenosine A1 receptor

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ADORA1
• Locus ID: 134
• Components:

  GA100093G1, Adenosine A1 Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100093G2, Adenosine A1 Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100093G3, Adenosine A1 Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000674, NM_001048230, NM_001365065, NM_001365066
• UniProt ID: P30542
• Synonyms: RDC7
• Summary: The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]