VPS37A (NM_001145152) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC227139L3V

Lenti ORF particles, VPS37A (Myc-DDK tagged) - Human vacuolar protein sorting 37 homolog A (S. cerevisiae) (VPS37A), transcript variant 2, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: VPS37A
• Synonyms: HCRP1; PQBP2; SPG53
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_001145152
• ORF Size: 1116 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC227139).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001145152.1, NP_001138624.1
• RefSeq ORF: 1119 bp
• Locus ID: 137492
• UniProt ID: Q8NEZ2
• Cytogenetics: 8p22
• Protein Pathways: Endocytosis
• MW: 41.3 kDa
• Gene Summary: This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]