SIK3 (NM_025164) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC223406L2V

Lenti ORF particles, SIK3 (mGFP-tagged) - Human SIK family kinase 3 (SIK3), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: SIK3
• Synonyms: L19; QSK; SEMDK; SIK-3
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_025164
• ORF Size: 3789 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC223406).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_025164.3, NP_079440.2
• RefSeq Size: 6072 bp
• RefSeq ORF: 3966 bp
• Locus ID: 23387
• UniProt ID: Q9Y2K2
• Cytogenetics: 11q23.3
• Protein Families: Druggable Genome, Protein Kinase
• MW: 139.8 kDa
• Gene Summary: Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity).[UniProtKB/Swiss-Prot Function]