ATP11C (NM_173694) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC222893L3V
- LentiORF®
Lenti ORF particles, ATP11C (Myc-DDK tagged) - Human ATPase, class VI, type 11C (ATP11C), transcript variant 1, 200ul, >10^7 TU/mL
Lentiviral Particles: mGFP w/ Puro
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USD 365.00
Specifications
Product Data | |
Type | Human Tagged ORF Clone Lentiviral Particle |
Tag | Myc-DDK |
Symbol | ATP11C |
Synonyms | ATPIG; ATPIQ; HACXL |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_173694 |
ORF Size | 3396 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC222893).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_173694.3, NP_775965.2 |
RefSeq Size | 6135 bp |
RefSeq ORF | 3399 bp |
Locus ID | 286410 |
UniProt ID | Q8NB49 |
Cytogenetics | Xq27.1 |
Protein Families | Transmembrane |
MW | 129.4 kDa |
Gene Summary | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. In the cell membrane of erythrocytes, it is required to maintain phosphatidylserine (PS) in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for splenic macrophages (PubMed:26944472). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity). Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity).[UniProtKB/Swiss-Prot Function] |
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