CPEB4 (NM_030627) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC221803L2V

Lenti ORF particles, CPEB4 (mGFP-tagged)-Human cytoplasmic polyadenylation element binding protein 4 (CPEB4), 200ul, >10^7 TU/mL

Product Images

RC221803L2 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC221803L2V particle to overexpress human CPEB4-mGFP fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: CPEB4
• Synonyms: CPE-BP4; hCPEB-4
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_030627
• ORF Size: 2187 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC221803).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_030627.1
• RefSeq Size: 6930 bp
• RefSeq ORF: 2190 bp
• Locus ID: 80315
• UniProt ID: Q17RY0
• Cytogenetics: 5q35.2
• MW: 80 kDa
• Gene Summary: Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3' UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity).[UniProtKB/Swiss-Prot Function]