SLC10A2 (NM_000452) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC221202L3V

Lenti ORF particles, SLC10A2 (Myc-DDK tagged) - Human solute carrier family 10 (sodium/bile acid cotransporter family), member 2 (SLC10A2), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: SLC10A2
• Synonyms: ASBT; IBAT; ISBT; NTCP2; PBAM
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_000452
• ORF Size: 1044 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC221202).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_000452.1, NP_000443.1
• RefSeq Size: 3779 bp
• RefSeq ORF: 1047 bp
• Locus ID: 6555
• UniProt ID: Q12908
• Cytogenetics: 13q33.1
• Protein Families: Druggable Genome, Transmembrane
• MW: 37.7 kDa
• Gene Summary: This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010]