CRLF2 (NM_022148) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC221190L1V

Lenti ORF particles, CRLF2 (Myc-DDK tagged) - Human cytokine receptor-like factor 2 (CRLF2), transcript variant 1, 200ul, >10^7 TU/mL

Product Images

RC221190L1 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC221190L1V particle to overexpress human CRLF2-Myc-DDK fusion protein.

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  RC221190L1 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC221190L1V particle to overexpress human CRLF2-Myc-DDK fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: CRLF2
• Synonyms: CRL2; CRLF2Y; TSLPR
• Mammalian Cell Selection: None
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_022148
• ORF Size: 1110 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC221190).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_022148.2
• RefSeq Size: 1579 bp
• RefSeq ORF: 1116 bp
• Locus ID: 64109
• UniProt ID: Q9HC73
• Cytogenetics: X;Y
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
• MW: 41.8 kDa
• Gene Summary: This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]