TRPM8 (NM_024080) Human Tagged ORF Clone Lentiviral Particle

SKU
RC220615L1V
Lenti ORF particles, TRPM8 (Myc-DDK tagged) - Human transient receptor potential cation channel, subfamily M, member 8 (TRPM8), 200ul, >10^7 TU/mL
  • LentiORF®
    LentiORF®

    Expression-ready ORF plasmid in lenti backbone

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  • Lenti

    Ready-to-use Lentiviral Particles

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$1,511.00
2 Weeks*
Specifications
Product Data
Tag Myc-DDK
Target Symbol TRPM8
Synonyms LTrpC-6; LTRPC6; trp-p8; TRPP8
Vector pLenti-C-Myc-DDK
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC220615).
ACCN NM_024080
ORF Size 3312 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_024080.3
RefSeq Size 5674 bp
RefSeq ORF 3315 bp
Locus ID 79054
UniProt ID Q7Z2W7
Cytogenetics 2q37.1
Domains ion_trans
Protein Families Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane
MW 127.5 kDa
Summary Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.[UniProtKB/Swiss-Prot Function]
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.