PML Protein (PML) (NM_033244) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC220236L2V

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  • LentiORF®

Lenti ORF particles, PML (mGFP-tagged) - Human promyelocytic leukemia (PML), transcript variant 5, 200ul, >10^7 TU/mL



USD 1,092.00


Availability*
6 Weeks

Size
    • 200 ul


Product images

Specifications

Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Symbol PML
Synonyms MYL; PP8675; RNF71; TRIM19
Mammalian Cell Selection None
Vector pLenti-C-mGFP
ACCN NM_033244
ORF Size 1680 bp
Sequence Data
The ORF insert of this clone is exactly the same as(RC220236).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_033244.3
RefSeq Size 3096 bp
RefSeq ORF 1683 bp
Locus ID 5371
UniProt ID P29590
Cytogenetics 15q24.1
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Acute myeloid leukemia, Pathways in cancer, Ubiquitin mediated proteolysis
MW 61.8 kDa
Gene Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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