Mesothelin (MSLN) (NM_013404) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC219757L1V

Lenti ORF particles, MSLN (Myc-DDK tagged) - Human mesothelin (MSLN), transcript variant 2, 200ul, >10^7 TU/mL

Product Images

RC219757L1 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC219757L1V particle to overexpress human MSLN-Myc-DDK fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: Mesothelin
• Synonyms: MPF; SMRP
• Mammalian Cell Selection: None
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_013404
• ORF Size: 1890 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC219757).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_013404.3
• RefSeq Size: 2076 bp
• RefSeq ORF: 1893 bp
• Locus ID: 10232
• UniProt ID: Q13421
• Cytogenetics: 16p13.3
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• MW: 68.99 kDa
• Gene Summary: This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]