bcl 6 (BCL6) (NM_001706) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC219007L4V

Lenti ORF particles, BCL6 (mGFP-tagged) - Human B-cell CLL/lymphoma 6 (BCL6), transcript variant 1, 200ul, >10^7 TU/mL

Product Images

RC219007L4 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC219007L4V particle to overexpress human BCL6-mGFP fusion protein.

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  RC219007L4 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC219007L4V particle to overexpress human BCL6-mGFP fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: BCL6
• Synonyms: BCL5; BCL6A; LAZ3; ZBTB27; ZNF51
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_001706
• ORF Size: 2118 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC219007).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001706.2
• RefSeq Size: 3537 bp
• RefSeq ORF: 2121 bp
• Locus ID: 604
• UniProt ID: P41182
• Cytogenetics: 3q27.3
• Domains: BTB, zf-C2H2
• Protein Families: Druggable Genome, Transcription Factors
• MW: 78.7 kDa
• Gene Summary: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]