p95 NBS1 (NBN) (NM_002485) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC214682L1V
- LentiORF®
Lenti ORF particles, NBN (Myc-DDK tagged) - Human nibrin (NBN), 200ul, >10^7 TU/mL
Lentiviral Particles: DDK w/ Puro mGFP mGFP w/ Puro
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Specifications
Product Data | |
Type | Human Tagged ORF Clone Lentiviral Particle |
Tag | Myc-DDK |
Symbol | p95 NBS1 |
Synonyms | AT-V1; AT-V2; ATV; NBS; NBS1; P95 |
Mammalian Cell Selection | None |
Vector | pLenti-C-Myc-DDK |
ACCN | NM_002485 |
ORF Size | 2262 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC214682).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_002485.4 |
RefSeq Size | 4639 bp |
RefSeq ORF | 2265 bp |
Locus ID | 4683 |
UniProt ID | O60934 |
Cytogenetics | 8q21.3 |
Domains | FHA |
Protein Families | Druggable Genome |
Protein Pathways | Homologous recombination |
MW | 84.8 kDa |
Gene Summary | Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008] |
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