GADD45B (NM_015675) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC213354L2V

Lenti ORF particles, GADD45B (mGFP-tagged) - Human growth arrest and DNA-damage-inducible, beta (GADD45B), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: GADD45B
• Synonyms: GADD45BETA; MYD118
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_015675
• ORF Size: 483 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC213354).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_015675.1, NP_056490.1
• RefSeq Size: 1121 bp
• RefSeq ORF: 483 bp
• Locus ID: 4616
• UniProt ID: O75293
• Cytogenetics: 19p13.3
• Domains: Ribosomal_L7Ae
• Protein Families: Druggable Genome
• Protein Pathways: Cell cycle, MAPK signaling pathway, p53 signaling pathway
• MW: 17.6 kDa
• Gene Summary: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]