MSH3 (NM_002439) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC212391L4V

Lenti ORF particles, MSH3 (mGFP-tagged) - Human mutS homolog 3 (E. coli) (MSH3), 200ul, >10^7 TU/mL

Product Images

RC212391L4V was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC212391L4V particles to overexpress human MSH3-mGFP fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: MSH3
• Synonyms: DUP; FAP4; MRP1
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_002439
• ORF Size: 3411 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC212391).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_002439.2
• RefSeq Size: 4645 bp
• RefSeq ORF: 3414 bp
• Locus ID: 4437
• UniProt ID: P20585
• Cytogenetics: 5q14.1
• Domains: MutS_V, MutS_I, MutS_III, MutS_II
• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: Colorectal cancer, Mismatch repair, Pathways in cancer
• MW: 127.2 kDa
• Gene Summary: The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]