Calcium Sensing Receptor (CASR) (NM_000388) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC211229L4V

Lenti ORF particles, CASR (mGFP-tagged) - Human calcium-sensing receptor (CASR), transcript variant 2, 200ul, >10^7 TU/mL

Product Images

RC211229L4 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC211229L4V particle to overexpress human CASR-mGFP fusion protein.

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  RC211229L4 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC211229L4V particle to overexpress human CASR-mGFP fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: Calcium Sensing Receptor
• Synonyms: CAR; EIG8; FHH; FIH; GPRC2A; hCasR; HHC; HHC1; HYPOC1; NSHPT; PCAR1
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_000388
• ORF Size: 3234 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC211229).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_000388.2
• RefSeq Size: 4913 bp
• RefSeq ORF: 3237 bp
• Locus ID: 846
• UniProt ID: P41180
• Cytogenetics: 3q13.33-q21.1
• Protein Families: Druggable Genome, GPCR, Transmembrane
• MW: 120.5 kDa
• Gene Summary: The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. [provided by RefSeq, Aug 2017]