IL12RB2 (NM_001559) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC211143L4V

  • LentiORF®

Lenti ORF particles, IL12RB2 (mGFP-tagged) - Human interleukin 12 receptor, beta 2 (IL12RB2), 200ul, >10^7 TU/mL

ORF Plasmid: DDK tGFP

Lentiviral Particles: DDK DDK w/ Puro mGFP mGFP w/ Puro


Special Offer: Buy this product and get 50% off Lenti Control Particles. Learn More.

USD 1,339.00

2 Weeks*

Size
    • 200 ul

Product Images

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Specifications

Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Symbol IL12RB2
Mammalian Cell Selection Puromycin
Vector pLenti-C-mGFP-P2A-Puro
ACCN NM_001559
ORF Size 2586 bp
Sequence Data
The ORF insert of this clone is exactly the same as(RC211143).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_001559.2, NP_001550.1
RefSeq Size 4040 bp
RefSeq ORF 2589 bp
Locus ID 3595
UniProt ID Q99665
Cytogenetics 1p31.3
Domains FN3
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
MW 97.1 kDa
Gene Summary The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]

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