COMP (NM_000095) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC211080L2V

Lenti ORF particles, COMP (mGFP-tagged) - Human cartilage oligomeric matrix protein (COMP), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: COMP
• Synonyms: CTS2; EDM1; EPD1; MED; PSACH; THBS5; TSP5
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_000095
• ORF Size: 2271 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC211080).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_000095.2
• RefSeq Size: 2471 bp
• RefSeq ORF: 2274 bp
• Locus ID: 1311
• UniProt ID: P49747
• Cytogenetics: 19p13.11
• Domains: EGF_CA, tsp_3, EGF, EGF
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: ECM-receptor interaction, Focal adhesion, TGF-beta signaling pathway
• MW: 82.9 kDa
• Gene Summary: The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016]