PKR (EIF2AK2) (NM_002759) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC210792L2V

Lenti ORF particles, EIF2AK2 (mGFP-tagged) - Human eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2), transcript variant 1, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: PKR
• Synonyms: EIF2AK1; LEUDEN; PKR; PPP1R83; PRKR
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_002759
• ORF Size: 1653 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC210792).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_002759.1
• RefSeq Size: 4361 bp
• RefSeq ORF: 1656 bp
• Locus ID: 5610
• UniProt ID: P19525
• Cytogenetics: 2p22.2
• Domains: pkinase, DSRM, TyrKc, S_TKc
• Protein Families: Druggable Genome, Protein Kinase, Transcription Factors
• MW: 62.1 kDa
• Gene Summary: The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]