DCK (NM_000788) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC210767L3V

Lenti ORF particles, DCK (Myc-DDK tagged) - Human deoxycytidine kinase (DCK), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: DCK
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_000788
• ORF Size: 780 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC210767).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_000788.1
• RefSeq Size: 2618 bp
• RefSeq ORF: 783 bp
• Locus ID: 1633
• UniProt ID: P27707
• Cytogenetics: 4q13.3
• Domains: dNK
• Protein Families: Druggable Genome
• Protein Pathways: Purine metabolism, Pyrimidine metabolism
• MW: 30.5 kDa
• Gene Summary: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]