Alkaline Phosphatase (ALPP) (NM_001632) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC210504L4V

Lenti ORF particles, ALPP (mGFP-tagged) - Human alkaline phosphatase, placental (ALPP), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: Alkaline Phosphatase
• Synonyms: ALP; ALPI; IAP; PALP; PLAP; PLAP-1
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_001632
• ORF Size: 1605 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC210504).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001632.3
• RefSeq Size: 2883 bp
• RefSeq ORF: 1608 bp
• Locus ID: 250
• UniProt ID: P05187
• Cytogenetics: 2q37.1
• Domains: alk_phosphatase
• Protein Pathways: Folate biosynthesis, Metabolic pathways
• MW: 58 kDa
• Gene Summary: The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. One of the main sources of this enzyme is the liver, and thus, it's one of several indicators of liver injury in different clinical conditions. In pregnant women, this protein is primarily expressed in placental and endometrial tissue, however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Aug 2020]