PPM1D (NM_003620) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC209328L2V

Lenti ORF particles, PPM1D (mGFP-tagged) - Human protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: PPM1D
• Synonyms: IDDGIP; JDVS; PP2C-DELTA; WIP1
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_003620
• ORF Size: 1815 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC209328).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_003620.2
• RefSeq Size: 3163 bp
• RefSeq ORF: 1818 bp
• Locus ID: 8493
• UniProt ID: O15297
• Cytogenetics: 17q23.2
• Domains: PP2C
• Protein Families: Druggable Genome, Phosphatase
• Protein Pathways: p53 signaling pathway
• MW: 66.5 kDa
• Gene Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]