ACE2 (NM_021804) Human Tagged ORF Clone Lentiviral Particle (Angiotensin Converting Enzyme 2)

CAT#: RC208442L2V

Lenti ORF particles, ACE2 (mGFP-tagged) - Human angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ACE2), 200ul, >10^7 TU/mL

Product Images

RC208442L2 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC208442L2V particle to overexpress human ACE2-mGFP fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: ACE2
• Synonyms: ACEH
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_021804
• ORF Size: 2415 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC208442).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_021804.1
• RefSeq Size: 3519 bp
• RefSeq ORF: 2418 bp
• Locus ID: 59272
• UniProt ID: Q9BYF1
• Cytogenetics: Xp22.2
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Renin-angiotensin system
• MW: 92.5 kDa
• Gene Summary: The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. [provided by RefSeq, Nov 2020]