Glutathione Peroxidase 4 (GPX4) (NM_002085) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC208065L2V

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  • LentiORF®

Lenti ORF particles, GPX4 (mGFP-tagged) - Human glutathione peroxidase 4 (phospholipid hydroperoxidase) (GPX4), transcript variant 1, (Note: selenocystein protein, Internal stop codon present. See Summary below), 200ul, >10^7 TU/mL

Product Datasheet for 'RC208065L2V'

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USD 820.00

3 Weeks

    • 200 ul

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Product Data
Product Name Glutathione Peroxidase 4 (GPX4) (NM_002085) Human Tagged ORF Clone Lentiviral Particle
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Symbol GPX4
Synonyms GPx-4; GSHPx-4; MCSP; PHGPx; SMDS; snGPx; snPHGPx
Vector pLenti-C-mGFP
Tag mGFP
ACCN NM_002085
ORF Size 591 bp
Sequence Data
The ORF insert of this clone is exactly the same as(RC208065).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info The expression of this clone is not guaranteed due to the nature of selenoproteins.
OTI Annotation This clone encodes a selenoprotein containing the rare amino acid selenocysteine (Sec). Sec is encoded by UGA codon, which normally signals translational termination. Expression of this clone is not guaranteed due to the nature of selenoproteins.
Reference Data
RefSeq NM_002085.3, NP_002076.1, NP_002076.2
RefSeq Size 936 bp
RefSeq ORF 594 bp
Locus ID 2879
Cytogenetics 19p13.3
Protein Families Druggable Genome
Protein Pathways Arachidonic acid metabolism, Glutathione metabolism
Gene Summary The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization. [provided by RefSeq, Dec 2018]
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Customer Reviews 
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