CysLT1 (CYSLTR1) (NM_006639) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC207763L2V

Lenti ORF particles, CYSLTR1 (mGFP-tagged) - Human cysteinyl leukotriene receptor 1 (CYSLTR1), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: CysLT1
• Synonyms: CYSLT1; CYSLT1R; CYSLTR; HMTMF81
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_006639
• ORF Size: 1011 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC207763).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_006639.2
• RefSeq Size: 1537 bp
• RefSeq ORF: 1014 bp
• Locus ID: 10800
• UniProt ID: Q9Y271
• Cytogenetics: Xq21.1
• Domains: 7tm_1
• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Calcium signaling pathway, Neuroactive ligand-receptor interaction
• MW: 38.4 kDa
• Gene Summary: This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]