DIP13B (APPL2) (NM_018171) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC207506L4V

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  • LentiORF®

Lenti ORF particles, APPL2 (mGFP-tagged) - Human adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (APPL2), 200ul, >10^7 TU/mL



USD 1,168.00


Availability*
6 Weeks

Size
    • 200 ul


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Specifications

Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Symbol APPL2
Synonyms DIP13B
Mammalian Cell Selection Puromycin
Vector pLenti-C-mGFP-P2A-Puro
ACCN NM_018171
ORF Size 1992 bp
Sequence Data
The ORF insert of this clone is exactly the same as(RC207506).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_018171.3
RefSeq Size 3289 bp
RefSeq ORF 1995 bp
Locus ID 55198
UniProt ID Q8NEU8
Cytogenetics 12q23.3
Domains PH, PID
MW 74.5 kDa
Gene Summary The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011]
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